![]() Chaudhry V, Rowinsky EK, Sartorius SE, et al. Chemotherapy-induced peripheral neuropathy and its association with quality of life: a systematic review. Has efficacy in significant reduction CIPN symptoms and improves quality of life of these patients.ġ. 21 (42%) patients has reported toxicities with burning but those are mild symptoms without quality of life effects. The efficacy and quality of life were constant after 1 week to 4 weeks after application. Global assessment of quality of life was improve by overall score. These 50 patients with CIPN reported significant reduction all of scoring at 4 weeks after application. A mixed effects linear regression model was applied to identify efficacy of topical capsaicin. These documents were collected at baseline, 1 week and 4 weeks after topical capsaicin application, including toxicities of this agent. Symptoms were monitored and followed using the numerical rating scale (NRS), Grading of neurotoxicity by NCI-CTCAE version 4.0 and questionnaires of neurotoxicity and quality of life in these toxicities (FACT/GOG-NTX and EORTC-QLQ CIPN 20). Baseline characteristics including primary cancer site, neurotoxic agent and cumulative dose, prior treatments were recorded. They were treated with topical capsaicin at area of neuropathy and neuropathic pain. ![]() Our study consisted of 50 patients with clinically confirm chemotherapy-induced peripheral neuropathy from various antineoplastic agents. This study assessed the efficacy of topical capsaicin in CIPN patients. There are no studies of capsaicin cream in CIPN. Topical capsaicin was approved in Thai FDA for these indications. Topical capsaicin is produced from chili pepper extraction and effective for treatment of neuropathic pain in diabetic neuropathy, postherpetic neuropathy and HIV-associated neuropathy. Current treatments for CIPN are largely ineffective. Department of Internal Medicine, Faculty of Medicine, Srinakharinwirot UniversityĬapsaicin, neuropathy, CIPN, chemotherapy, topical AbstractĬhemotherapy-induced peripheral neuropathy (CIPN) is a commonly problem entity following many chemotherapies for cancer therapy, among which sensory abnormalities and pain are common and the most suffering issues. ![]()
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